Belly Fat May Drive Inflammatory Processes Associated with
Disease
Newswise — As scientists learn more about the key role of inflammation in
diabetes, heart disease and other disorders, new research from Washington
University School of Medicine in St. Louis suggests that fat in the belly may be
an important promoter of that inflammation.
Excess fat is known to be associated with disease, but now the researchers
confirmed that fat cells inside the abdomen are secreting molecules that
increase inflammation. It's the first evidence of a potential mechanistic link
between abdominal fat and systemic inflammation.
For years, scientists were aware of a relationship between disease risk
and excess belly fat. "Apple-shaped" people, who carry fat in the abdomen, have
a higher risk of heart disease, diabetes and other problems than "pear-shaped"
people, who tend to store fat in the hips and thighs. Too much abdominal fat is
associated with a defect in the body's response to insulin. During medical
exams, some physicians measure waist circumference to identify patients at
increased risk for these problems.
Not just any belly fat will cause inflammation, however. Back in 2004,
Washington University investigators found that removing abdominal fat with
liposuction did not provide the metabolic benefits normally associated with
similar amounts of fat loss induced by dieting or exercising.
"Despite removing large amounts of subcutaneous fat from beneath the skin —
about 20 percent of a person's total body fat mass — there were no beneficial
medical effects," says Samuel Klein, M.D., the Danforth Professor of Medicine
and Nutritional Science and the senior investigator on both studies. "These
results demonstrated that decreasing fat mass by surgery, which removes billions
of fat cells, does not provide the metabolic benefits seen when fat mass is
reduced by lowering calorie intake, which shrinks the size of fat cells and
decreases the amount of fat inside the abdomen and other tissues."
In this new study, researchers looked instead at visceral fat — the fat that
surrounds the organs in the gut. Unlike subcutaneous fat, visceral fat is not
easy to remove surgically because it is very close to the intestines and other
internal organs. Since they couldn't just take out the fat, the research team
decided to analyze the blood that ran through it to determine whether visceral
fat was involved in inflammation or whether, like subcutaneous fat, it was
merely a marker of potential problems.
Reporting in the journal Diabetes, the research team says visceral fat
likely contributes to increases in systemic inflammation and insulin resistance.
They sampled blood from the portal vein in obese patients undergoing gastric
bypass surgery and found that visceral fat in the abdomen was secreting high
levels of an important inflammatory molecule called interleukin-6 (IL-6) into
portal vein blood.
"The portal vein is filled with blood that drains visceral fat," says first
author Luigi Fontana, M.D., Ph.D., assistant professor of medicine at Washington
University in St. Louis and an investigator at the Istituto Superiore di Sanita,
Rome, Italy. "Portal vein blood had levels of IL-6 that were 50 percent higher
than blood from the periphery."
Increased IL-6 levels in the portal vein correlated with concentrations of an
inflammatory substance called C-reactive protein (CRP) in the body. High CRP
levels are related to inflammation, and chronic inflammation is associated with
insulin resistance, hypertension, type 2 diabetes and atherosclerosis, among
other things.
"These data support the notion that visceral fat produces inflammatory
cytokines that contribute to insulin resistance and cardiovascular disease,"
says Klein.
Klein, Fontana and J. Christopher Eagon, M.D., assistant professor of
surgery, looked at blood samples from 25 patients. All were extremely obese, and
all were undergoing gastric bypass surgery. They took blood from the portal vein
and from the radial artery in the arm and found differences in levels of IL-6
between the samples.
Fontana believes the findings help explain how visceral fat can lead to
inflammation, insulin resistance and other metabolic problems. And he says by
contributing to inflammation, visceral fat cells in the abdomen may be doing
even more than that.
"Many years ago, atherosclerosis was thought to be related to lipids and to
the excessive deposit of cholesterol in the arteries," Fontana says. "Nowadays,
it's clear that atherosclerosis is an inflammatory disease. There also is
evidence that inflammation plays a role in cancer, and there is even evidence
that it plays a role in aging. Someday we may learn that visceral fat is
involved in those things, too."